People want and expect pretty and interactive experiences.
I don't think they care how they get there.
I've written some Unity "web" apps by using the port to webgl feature, so I have no deep fondness of html or js. I just need results.
With a little creativity, HTMX can enable some extremely UX-friendly interactive sites. Keep in mind that it makes it trivially easy to entirely swap out small, or large, sections of a web page. So things that used to be standard boring forms can be interactive step-by-step pathways that adapt to the user's selections. Very easy to deliver progress updates and validation cues to users that seem to appear magically without page reloads. It's still early but HTMX continually inspires me (a poor designer) to execute new UI ideas because it makes it very simple to conceptualize how they can be built (and simple to actually build). Tailwind is also essential in this process, for me.