Install PyWin32 module and `import win32com.client` and you can access "all the internal Excel objects and methods that VBA has access to".
C:\>python
Python 3.10.1 (tags/v3.10.1:2cd268a, Dec 6 2021, 19:10:37) [MSC v.1929 64 bit (AMD64)] on win32
Type "help", "copyright", "credits" or "license" for more information.
>>> from win32com.client import Dispatch
>>> xl = Dispatch("Excel.Application")
>>> xl.Visible = True
>>> wb = xl.WorkBooks.Add()
>>> sh = wb.WorkSheets[0]
>>> sh.Range("A1").Value = "Hello World"
>>>