With 400 daily users in the CRM, mysql is not a problem at all. The only problem I have is loading huge tables sometimes without using pagination, but that's from a connection speed problem to the user not a mysql problem. Sometimes the table makes it towards 10+ megabytes and thats a bit goofy.
My question was more based on should I learn the new tech, or any new tech, if I'm now building something I hope will have atleast several thousands daily active users.
Deep down I know the answer. It's pretty obvious mysql won't have problems even for a million users for most types of sites.