He mentions police showing up at someone's work regarding a tweet reported as hate-speech. Not really a laughing matter. It's a waste of police resources for starters.
Dawkins is not compelling reading on this subject. But I did find it funny the connection he makes between 1984's "2+2=5" and "her penis"... I chuckled at that!
I read your other comments here. You are pushing for Dawkins to sit down and chat with more trans people and discuss all these things, rather than throw stones from a place that looks a bit like intolerance or out of touch. Nothing wrong with that idea. Bring on the debate! The difference is that instead of his usual atheism subject matter, where God literally can't join the debate, it's now possible for the subject of his complaints to step up and answer his questions and concerns. I agree I think it should happen.