Initially I got the most downvotes I think I'd ever seen†, and then Thomas realised oops, yeah, he's not saying what I thought he's saying and it shot back up over the course of an hour or so. IIRC the auto-transcripts for example transcribe PKIX (an RFC explaining how we shall use the X509 certificate system for the Internet, and the regime resulting from that RFC) as "Peacocks". Hilarious. But, not a criticism of the person on the show (Ryan Sleevi I believe, who I rather like although we've never met in person).
I have written things I don't feel good about, especially trolling groups who believe something I don't, and deserved to be downvoted even if they were strictly true. But those mostly get -1 or -2 or something. Thomas' fans just keep hitting that down arrow apparently.
Other than disagreeing with Thomas, the main way I got sizeable negative voting was being wrong and then going to sleep without correcting it. Say 2+2 = 3 on a Thursday evening, but correct it to "1+2 = 3" a quarter hour later? Probably get one or two downvotes. Leave it that way overnight? Wake up to 10 downvotes at least. People will kick you if you don't react.
I remember picking an erroneous example in one of the endless Rust v C++ threads, and then going to bed, and yup, very clear I was wrong when I woke up.
A comment should be evaluated on its own, not based on who it was written by.
For example, if a comment claims an article is wrong about the development and use of the Nagle algorithm, I am very much not well-equipped to evaluate the comment on its own since that is not an area I know much about. If I see that comment was written by Animats, though, I can be reasonably confident I should trust the comment over the article, since he invented the algorithm.
I try to avoid looking at the names until after the discussion is over. When I remember the fact I'm posting among giants, I find it difficult to post at all. HN is a place where the person who created an algorithm shows up to explain it to you. The fact such people post here is the number one reason to come here.