Microsoft terminating the agreement by which they supply compute to OpenAI and OpenAI licenses technology to them would be an existential risk to OpenAI (though other competing cloud providers might step in and fill the gap Microsoft created under similar terms), but -- whether or not OpenAI ended up somewhere else immediately (the tech eventually would, even if OpenAI failed completely and was dissolved)
Microsoft would go from the best positioned enterprise AI cloud provider to very far behind overnight.
And while that might hurt OpenAI as an institution more than it hurts Microsoft as an institution, the effect on Microsoft's top decision-makers personally vs. OpenAI's top decisionmakers seems likely to be the other way around.