Generally people that continue reading through TAOCP and invest the time and effort in doing so do get value from that or are foolish to keep going.
I read the early volumes thoroughly in the 80s and 90s and got a lot of insight into, for one example, methods for constraining error when doing chained numerical calculations.
His approach alone was inspiring at the time even if specific chapters weren't of any immediate interest.
They're not especially useful for general journeyman programmers and they're but one star in the firmament for people aiming higher .. but they are worth the effort if the material is of interest.
