You can look at the history of PyObject yourself: https://github.com/python/cpython/commits/main/Include/objec.... None of these changes were done because of weird CPU errata that meant that making the header bigger was a performance win. That isn't to say that the developers wouldn't be interested in such effects, or be able to detect them, but the fact that the object header happens to be large enough to avoid the performance bug isn't because of careful testing but because that's what they ended up for other reasons, far before Zen 3 was ever released. If it so happened that Python was affected because the offset needed to avoid a penalty was 0x50 or something then I am sure they would take it up with AMD rather than being content to increase the size of their header for no reason.