>The point isn't to design for the lowest common denominator, but for the users you will actually have
Keyword: situational disability
Even a perfectly fit and educated target audience sometimes suffers from certain conditions or in an environment that significantly reduces their mental or physical capacity. Stress, injury, pregnancy, too many beers, very long nails, terrible weather, a toddler trying to grab your phone, non-native speaker etc etc. You may know the user even personally, but you never know what’s going on in their lives when they use your app. So general advice: ALWAYS follow accessibility guidelines. Even bad copy may drop your usage by a significant percentage, because there are plenty of people with dyslexia.