Can you please not post in the flamewar style? You've broken the site guidelines here and we've already had to ask you not to do that.

https://news.ycombinator.com/newsguidelines.html

Edit: actually, since your recent comments look like this, I've banned the account:

https://news.ycombinator.com/item?id=39341879

https://news.ycombinator.com/item?id=39341602

https://news.ycombinator.com/item?id=39341585

https://news.ycombinator.com/item?id=39341578

https://news.ycombinator.com/item?id=39308894

https://news.ycombinator.com/item?id=39281272

https://news.ycombinator.com/item?id=39249635

https://news.ycombinator.com/item?id=39238628

https://news.ycombinator.com/item?id=39237978

That's completely unacceptable on HN. If you don't want to be banned, you're welcome to email hn@ycombinator.com and give us reason to believe that you'll follow the rules in the future.

‘Utterly wrong’ is a harsh conclusion. You may want a touch of humility yourself. Amyloid plaques are the defining feature of AD and assuredly provide vital clues about the biomolecular processes driving AD across the brain. There is renewed interest in the what causative role amyloid plays [1]. Whether plaques are causative or a byproduct is an open question, especially when we consider the heterogeneity in neurodegenerative diseases. AD itself probably is an umbrella term capturing several subtypes (such as CAA). Whatever role amyloid plays, the OP is correct: correlates open interesting research avenues and this is an interesting paper if for no other reason we have few predictors of who will develop AD.

[1] https://www.nature.com/articles/s41392-023-01484-7

Hmm. Are you saying that the fact that some knowledge is wrong means that it doesn’t represent progress?

Correlation isn’t “cure” — we don’t even know if it’s predictive — but that doesn’t mean it’s not progress.

I agree with you. I think being proven utterly wrong is a huge accomplishment nonetheless. We shouldn’t be sure of ourselves, but we should treasure any progress even if it’s in the form of negating causes rather than isolating them.