Sure, you do you. I spent 10 years working with jQuery and am very thankful to leave that very far behind me.
BTW: jQuery is 85.1 kB minified and 29.7 kB gzipped. Preact (same API/dev experience as React, minimal performance impact) is 11.4 kB minified and 4.5 kB gzipped. Who has the smaller JS bundle now?