Coronavirus were thought to be non-vaccinable, even worse than the flu. They are behind a lot of winter colds, and they are a great pain in veterinary. Veterinaries are the ones that were pessimistic before mRna vaccines, because they were trying vaccines for decades to no avail.

Measless and chickenpox are very stable, and even the body gains inmunity for life just being exposed to it in the childhood.

All of them are virus the same way an ant and a elephant are animals. You might kill the ant with a magnifying glass, but good luck trying with th elephant.

> repeated doses have been shown to induce IgG4 production

I have a strong suspicion that this finding explains some if not all of the weird results with these vaccines.

* The 95% effective was a measurement solely of sickness, not infection. At the time this was reported, we had no idea if this meant it prevented infection/improved the immune response (good) or suppressed the immune response so we didn't develop symptoms (bad).

* Tons of countries had huge infection spikes just a couple months after reaching high vaccination rates.

* "Long Covid" seems to have become far more prevalent after the vaccines than before.

Here's what I think is happening: The IgG4 finding is key in explaining all of these. It suppresses the immune response, which would allow the virus to run wild without any immediate symptoms (95% initial efficacy). This could cause small amounts of damage that accumulate into Long Covid (why it's associated with infection but seems more prevalent in vaccinated people), as well as turn the vaccinated into asymptomatic spreaders (the high infection spikes).

Personally, I think mRNA vaccines were a complete failure.

Measles and chickenpox are both respiratory and airborne. The serial interval is longer though, gives the vaccines more time to work to prevent transmission. Though, the chickenpox vaccine is more of a "parental time off work harm reduction" thing, however the newer shingles vaccines make that somewhat less so, as the combined vaccines do probably have a RRR on getting symptoms for your whole life.

Edit: not to say there's no "positive" effect on the total death rate (i.e. the vaccine causes there to be less deaths overall), it's just not a cost effective positive effect considered in isolation.

The new vaccines are always outdated by the time they get to market, it just mutates too fast. For example Omicron emerged in November 2022, and booster shots for Omicron weren’t available until far later. And now the disease is much more diverse.

No vaccine technology will be able to solve that on its own. There would need to be a significant change in risk tolerance of approving and manufacturing vaccines and deploying them on a rapid timescale.

> Measles and Chickenpox are both airborne, although they’re not respiratory the way Covid is. But their respective vaccines are vastly more effective.

Natural infection with Measles and Chickenpox are also vastly more effective at preventing reinfection than natural infection with SARS-CoV-2. It is a property of the virus, not the vaccine.