This dynamic means that folks who own what you correctly categorize as owning "detached single family homes in (or close) to desirable cities" who no longer care about the commute might be overall willing to sell these homes in favor of larger/more affordable homes further out, freeing up these homes to those for whom city proximity still matters.
I think there are really two core demographics at play with a small middle. There are those who are all about the city life - don't want a car, don't want a house, want to walk to work and to the tinder date, be around a large number of diverse people and experiences, etc. Then there are those who primarily orient their life around home/family and want the space/affordability. Distance to city mainly matters as a factor of the commute, which itself is less relevant than it was before.
Then there's the relatively smaller group that both wants a house and needs to be close to the city life. This group will continue to pay the highest costs because they have the highest demand but I think that's reasonable.