Do you primarily work with invalids or children? Heck, even children can kill, but it usually requires working together. I was reading the other day about a group of under 10yos that buried alive another kid in a village because he looked weird.
Of everyone person I've ever met between the ages of 16 and 60, I'd say 99% are physically capable of killing somebody - you only need to push someone at the right time to have them fall to their death. Frail old woman have killed babies by covering their faces. There are poisonings.
Do guns make it easier or more accessible? Absolutely. Can a 95 lbs woman physically take on a 250 lbs man? Not likely in a 1:1 fight, but I met one who killed her husband with a knife.