A big step forward for the USA would be a vast reduction of federal power over the states.
However, there is a very solid case for a weak federal government, and it is simply that US is a country that's way too big for any coherent national policy on most matters that we've currently pushed there. It's such a vicious fight because it's half the country trying to bludgeon the other half into submission, motivated by the knowledge that, if you yield, the other guy will pick up this huge club and do the same to you. This will continue until the country breaks down unless we dial it down to state level and accept the fact that other states may have laws and lifestyle that is despicable or horrifying to us in some ways. Either that, or we might as well just break the whole thing apart now and not wait for it to happen in a more violent manner.
The US is a massive country, with the populace far removed from the decision making. I believe this is the core problem.