A few weeks ago, I was unable to log in to Google on a new device with my 2FA token (Yubikey) because Google insisted on authenticating with a passkey/resident key, but the token had only been set up with non-resident TOTP or whatever it's called (and had been working properly in this mode for over a year). I was able to log in on another device and register the Yubikey with a passkey/resident key, but it was really scary! There is so much complexity here, and so little visibility and control afforded to users, that I feel very uncomfortable trusting it as my only login method for any moderately important service.
It's possible this was a Mac OS problem, but I don't think it really matters. Either way, this stuff needs to be absolutely rock solid and frictionless if normal people are going to use it safely, and it obviously isn't.