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0 pointsodyssey71y ago0 comments

Does everybody with two copies get Alzheimer’s? If not, then there must be at least one additional ingredient / cause.

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tupshin1y ago

> Not only were people with two copies of the APOE4 gene much more likely to develop the biological changes that lead to Alzheimer’s disease, similar to people with the other genetic forms of the disease, they were almost assured the diagnosis: Nearly 95% of the people in the studies with two copies of the APOE4 gene had the biology of Alzheimer’s disease by the time they were 82 years old.

odyssey7OP1y ago

What percentage of people have microplastics in their body? Or have been previously infected by common childhood illness? I’m not giving these as theories for Alzheimer’s etiology, but to show that some environmental factors are ubiquitous.

Just because an environmental factor is ubiquitous—-or is ubiquitous within the frame of some sampling bias for the study—-doesn’t mean we should conclude the cause does not exist.

mistersquid1y ago

> What percentage of people have microplastics in their body? Or have been previously infected by common childhood illness? I’m

Unless 95% of these populations also are assured an Alzheimer's diagnosis by 82, your chosen confounding statistics may have little bearing on how closely double copies of the APOE4 gene is associated with Alzheimer's diagnoses.

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zybftjmvs1y ago

If a person is given an IV line, wouldn't friction introduce micro plastics into their body?

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