Good question, this is what most modern studio engineers would do, especially given that more and more speakers (like the Neumann KH120 II) feature internal FIR filters so you can calibrate them using measurement microphones.

Many modern Studios run some form of digital audio network as well (Dante, Ravenna, etc) so you can go digital as early and close to the source as possible and do all the routing using network switches and some sort of managment software (e.g. Dante Domain Manager). So if you do that it makes sense to go digital all the way to the speakers and convert directly to analog there after running through a DSP that allows you to correct for the speakers position in the room.

Cables can matter. But more for mechanical reliability, good shielding and perfect handling after years of use than any other magical properties. If you want to run balanced audio signals at miniscule loss for a few thousand meters it turns out that you can just use CAT6 for that. These cable are made for far more challenging (speak: higher frequency) signals and they have a track record of working.