From my hearsay, you absolutely can, given two things: fewer pointer-chasing data structures, and, most crucially, fewer or no allocations. Pre-allocate arrays of things you need, run ring buffers on them if you have to use a varying number of things.
A fun but practical approach which I again heard (second-hand) to be used, is just drowning your code in physical RAM, and switch the GC completely off. Have enough RAM to run a trading day, then reboot. The cost is trivial, compared to spending engineering hours on different approaches.