I find that most JS projects work fairly well: "npm install" maybe followed by "npm run build" or the like. This isn't enforced by npm and I don't think npm is perfect here, but practical speaking as a non-JS dev just wanting to run some JS projects: it works fairly well for almost all JS projects I've wanted to run in the last five years or so.

A "run_me.py" that would *Just Work™" is fine. I don't overly care what it does internally as long as it's not hugely slow or depends on anything other than "python". Ideally this should be consistent throughout the ecosystem.

To be honest I can't imagine shipping any project intended to be run by users and not have a simple, fool-proof, and low-effort way of running it by anyone of any skill level, which doesn't depend on any real knowledge of the language.