Depending on your sector, I would argue that in IT, lives can be at stake. Imagine the IT department of a hospital, a power company, or other vital infrastructure.
Most mitigation tends to be in the form of backup and disaster recovery plans, which, when well implemented and executed, can restore everything in less than a day.
The issue is that some threats can lurk for weeks, if not months, before triggering. In a car analogy, it would be like someone sabotaging your airbag and cutting your seatbelt without you knowing. Preventing a crash in the first place is far more effective and way less traumatic. Even if the mitigation strategy allows you to survive the crash, the car could still be totaled. The reputation loss you suffer from having your database breached can be catastrophic.