Easy, mastering the language (everything you can do with it, everything!), the main language runtime, the C extensions API, and the complete standard library.
Then just like C++, add the set of key implementations, CPython, Cython, PyPy, key libraries everyone uses (parallel to Boost).
Since you have such a wide Python experience, naturally you already printed out all the PDFs of Python documentation, and read them cover to cover.
I did such thing back on Python 2.0 days, and it only grew bigger.
How many pages was it again?