I used this when doing analysis. It's pretty good. https://www.numbeo.com/cost-of-living/comparison.jsp
From a pure cost, POV you burn most of your money on rent and food. When we had visitors, I had to plan out my budget to cover meals for everyone. I remember paying >$80 for a decent bagels+coffee breakfast for me, my wife and her parents.
In terms of security, If you keep your head on a swivel then you're fine. I had the same alertness that I have when traveling a foreign country. You need to be on high alert all the time.
Otherwise is it's a wonderful place. If I was a single guy, I'd love the vibe, the people, and the opportunity. If your in a WFH situation then I'd suggest just trying it out for 6 to 12 months. The experience will be great either way.
Other place id recommend is the Folsom near Sacremento. It's ~1 hour to lake tahoe and lots of nature to enjoy there. Very suburban WFH tolerant with roughly 50% of the rental cost