IMO the python JIT support won't help very much. Python currently is ~50x slower than "fast" languages, so even if the JIT provides a 3x speedup, pure python will still be too slow for anything that needs performance. Sure it will help on the margins, but a JIT can't magically make python fast.
It depends on whether you’re transforming data out of files or whatever to get it into these libraries to start with to be fair. Overall I wouldn’t expect that to have an effect on a long-running computation but when starting up a project it can be a bit slow.