Gnome though usually just works and has well thought out defaults, so you're usually just hampering yourself with changing them. For navigating the desktop and windows I rarely have to touch the keyboard, and it works so well I don't even have the need for a secondary or larger display.
KDE et all OTOH have tend to have poorly thought out defaults leading to inconsistent mess of an inteface littered with random configuration options. A big reason for this is likely the user community who like to be "power users" by clicking buttons and refusing to learn text configuration, let alone extensions. And the DE devs then give in to the users demanding a configuration option to select a specific cat picture as the menubar background.