IMO the biggest detriment of VC-backed companies is that they can still get killed when they're profitable because they're just not profitable
enough.
You found a company and own 100%. You get investment and bring on partners, you set aside 20% for employee shares, etc. All of a sudden there's a dozen owners and nobody owns 50%. You're profitable in the sense that everyone's payroll clears and you're making rent, with money left over, but it's not enough to invest in anything big, and the investors won't put up anything more because your growth has stalled.
Every investor who was previously your "partner" will be trying to shut the company down and sell it for parts.
VCs don't make their money by having a portfolio of companies throwing off $200k/yr in profit to a dozen different investors.