It isn't really notable because those PE multiples are literally just noise. There are many companies with negative PE on that list too, even though that makes no sense.

To take that even further, imagine ACME Corp.'s stock price is $1.00 today. You're a research analyst and built a very robust model based on your understanding of the company, the market in which it operates, corporate guidance, competitor performance, your experience, phone checks with the sales channel, etc. Your model currently says the company will have negative ($0.01) EPS over the next 12 months. Based on this information, its implied forward P/E multiple is -100.0x.

The next day, you come to work and update your model based on some new information like the Fed cutting rates by 25 bps or revised labor market assumptions, what have you, such that your expected next twelve months EPS is now positive $0.01. The implied trading multiple is now 100.0x.

Do you think a $0.02 change in the expected EPS should result in a 200.0x P/E difference? No, it shouldn't. The P/E ratio for a company with negative or near-zero earnings has no meaning.

Kind of conveniently cut off the first part of the statement there. The basis of fundamental valuation, discounted cash flow analysis, looks at all cash flows, forever, into the far future until the company dies. For a sufficiently mature company, current earnings are reasonably considered a good approximation of future earnings. For a newer company that is growing rapidly and spending most of its cash on long term investments rather than current year operations, it is not. Otherwise, every new company that has no earnings yet would be worthless, or if you consider losing money to be negative earnings, you're saying they should be paying you to own them.

No, it's just the trading multiples derived from them that are totally wrong for the purposes of valuing the company today, because the Ks and Qs pertain to the past, which we cannot visit.