Common lisp is in fact a good point of comparison once you look at how it's fast. The trick with Common Lisp is that they made a foundation of stuff that can actually be optimized pretty well by a compiler, and made that stuff exempt from being changed on the fly (or in some cases, just made the the compiler assume that they won't change on the fly even if they do, resulting in seg-faults unless you recompile code and re-generate data after changing stuff).
This is how Common Lisp people can claim that the language is both performant and flexible. The performant parts and the flexible parts are more disjoint than one might expect based on the way people talk about it.
But anyways, Common Lisp does manage to give a high degree of dynamism and performance to a point that it surely can be used for any of the dynamic stuff you'd want to do in Python, while also giving the possibility of writing high performance code.
Python did not do this, and so it'll be impossible for them to offer something like common lisp perf without breaking changes, or by just introducing a whole new set of alternatives to slow builtins like class, int, call, etc.
