Because of GIL, there may be at most one thread in a Python process running pure Python code. If I have a computation which takes 10% time in pure Python, 90% time in C extensions, I can only launch at most 10 threads, because 10 * 10% = 100%, and expect mostly linear scalability.

> the pure Python code in between calls into C extensions is irrelevant because you would not apply multithreading to it

No. There is a very important use case where the entire computation, driven by Python, is embarrassingly parallel and you'd want to parallize that, instead of having internal parallization in each your C extensions call. So the pure Python code in between calls into C extensions MUST BE SCALABLE. C extensions code may not launch thread at all.