Yeah, I also target Chrome and Firefox. I'll occasionally test on Edge.
I had a user report that pinyin was looking funny on Reddit. Turns out they use a system font stack which includes Verdana (and so only shows up on Windows), and Verdana does really poorly with Pinyin ruby (iirc it was a generic ruby thing, not just Pinyin).
I just replaced it with a custom system font stack without Verdana.
Not a difficult fix, but something to be aware of.