https://github.com/astral-sh/python-build-standalone is by the same people as uv, so it's hardly random. The releases there include ones with profile-guided optimisation and link time optimisation [1], which are used by default for some platforms and Python versions (and work seems underway to make them usable for all [2]). I don't see any recommendation against using their binaries or mention of optimising for portability at the cost of performance on the page you link or the pages linked from it that I've looked at.
[1] https://github.com/astral-sh/uv/blob/main/crates/uv-python/d... (search for pgo)
[2] https://github.com/astral-sh/uv/issues/8015