I actually did try to install Qubes over the holiday, but I repeatedly encountered installation failures and could not ever login to the system. Someone had posted an identical issue, but they were similarly stymied. I should revisit, but my initial foray tells me I am going to have to withstand quite a few papercuts in order to get the isolation I want.
never had issues with qubes like that but i did pick something tested (hw). u can check hardware compat list. it has also some good links to forums for specific hw related tweaks u might need.
that being said, runing qubes fully and workin with it is something else... i decided i am uninteresting enough just to use ubuntu these days :p... maybe sometime ill have the patience again.