Bespoke audio. Command your characters with your voice, not just the mouse. (They might argue or remind you of their other abilities or tactics if they don't feel you are utilizing them maximally.)
The opponents have to use it too, which can open new game mechanics around silence or distracting noise.
Jealous NPCs. Space-sim banter. Follow-up plot points based on adhoc conversations.
What if we can't click the right dialogue all the time; we have to convince them from our experience.