I was part of a research lab on grants like that. We had close to $1m in total funding, on top of that indirect was like 50% (so $500k/year) We maybe had 4000 sq. foot of lab space in an old building that wasn't maintained well. We had one bathroom for each gender on the floor for the research arm of two whole medical departments. Two admins for the whole research department of 7-8 labs totallying maybe 60-70 staff.
I ran the numbers and the lab space would have maybe cost $100k/year tops (probably more like $80k, depending on quality) if we were rent out equivalent industrial office space. On top of that you have electrical, heating, telecom, at most $10k. Support services such as HR, cleaning, IT support (of which we didn't use a whole lot) could have been contracted out, at most around $20k. So there was about $350k which I figured was mostly just a subsidy and went to "administration". Not that I was philosophically opposed to it, except maybe the admin.