It also requires more thought and strategy at every point rather than "wait for line to go up and click buy on anything available"
The biggest difference is that you can lose Balatro, and you can lose it very quickly either due to bad luck or bad strategy. In Universal Paperclips nothing matters, once you get the most basic automation both the game and you are proceeding towards the heat death of the universe and all you can do is accelerate it.
It's also a time boxed game - if you ignore the Civilization "one more turn" effect, any given game will be over within 20 minutes.