Uv takes the position that since it’s so fast to install dependencies and create environments, you don’t maintain a global venv.

  uvx ruff file.py

Otherwise you can:

  uv run —-with package file.py

https://docs.astral.sh/uv/guides/scripts/#running-a-script-w...

Or better, do the above, then create a virtual env, set the virtual env in your.bashrc and install everything into that

Better still... use uv script --init See other comments on this post

  alias newpy='function _newpy() { 
      default_deps=("rich" "requests");
      uv init --script "$1" && uv add "${default_deps[@]}" --script "$1"; 
  }; _newpy'