So, I like this idea, I really do. At the same time, in the short-term, WASM is relatively messy and, in my opinion, immature (as an ecosystem) for prime time. But with that out of the way (it will eventually come), you'll have to tell people that they can't use any code that relies on threads, so they better know if any of the libraries they use does it. How do you foresee navigating this? Runtime errors suck, especially in this context, as fixing them requires either live patching code or migrating execution logs to new code versions.
