I run a Sliger 3701 [0] with an ASRock Rack Ryzen motherboard (choose B650D4U or X570D4U to suit) using TrueNAS Scale. This replaced my old FreeNAS Atom C2000 setup that ran for over a decade with zero issues.

Add in a Mikrotik CCR2004-1G-2XS-PCIE [1] for high speed networking. Choose your own HBA.

0: https://www.sliger.com/products/rackmount/storage/cx3701/

1: https://mikrotik.com/product/ccr2004_1g_2xs_pcie