From what I can tell, a partial refresh of the display (updating a smaller portion of the screen) performs less wear on the display than a full refresh, but it can still accumulate over time. Additionally some displays will require a full refresh after a certain number of partial refreshes to deal with ghosting.

I don't know about this display but I've tinkered a bit with Waveshare E-Ink, that has this disclaimer:

"For e-Paper displays that support partial refresh, please note that you cannot refresh them with the partial refresh mode all the time. After refreshing partially several times, you need to fully refresh EPD once. Otherwise, the display effect will be abnormal, which cannot be repaired!"

https://www.waveshare.com/wiki/1.54inch_e-Paper_Module_Manua...