What is serious business? I think supabase can scale brilliantly, and it doesn't lock you in, if you have need for some special infra you can build and integrate it, I don't know but you could possibly even use FDW to access a postgres you run yourself.
Also they can't run on AWS postgres with all their postgres plug-ins AFAIK.
The point of "cheaper to host everything yourself" is a lot higher than what most estimate.
My only concern is that is supabase goes out of business or go evil you're gonna have a bad time, however everything is open-source