"Home page should load under 2 seconds at P95", "reports should load under 10 seconds at P99", "this background task should take under 30 seconds at P99".
Having these targets (and, frankly, remembering in the B2B space is that the status quo is _so slow_) can let you set performance objectives without chasing milliseconds that you don't need to.
Django has a lot of intrinsic slowness to it, "easy" DB access patterns often lead to heavy messes, but if at the end of the day most customers are getting served under some benchmark you can reap the advantages of the tooling without sweating perf too much.
And when you set these SLOs, you can then push for even tighter ones as you figure out your problem space!
In the B2B space companies get away with _so much_ sluggish behavior, if you're better than the median that's already improving things.