Would be interested to know what others have set up as I'm not really happy with how I do it. I have zfs on my NAS running locally. I backup to that from my PC via rsync triggered by anacron daily. From my NAS I use rclone to send encrypted backups to Backblaze.
I'd be happier with something more frequent from PC to NAS. Syncthing maybe? Then just do zfs sync to some off site zfs server.