You can adjust your language depending on the biological gender of who you're addressing in English, but English doesn't have grammatical gender in any meaningful way. The concepts are largely orthogonal.
Calling it gender really is just a bad, misleading name in the grand scheme of things.
Edit: see German example: https://en.m.wikipedia.org/wiki/Grammatical_gender_in_German
Hon slår tolv. 'She strikes twelve', referring to the clock currently striking.
It literally means he and she in Latin. Then people started using these to indicate that something was a specific object instead of an object in general.