Depends on what one means by that.
Dedicated hardware? I doubt that we’ll ever see that again, although of course I could be wrong.
A full OS? That’s more likely, but only just. If it had some way to run Windows, macOS or Linux programs (maybe just emulation?) then it might have a chance.
As a program? Arguably Emacs is a Lisp Machine for 2025.
Provocative question: would a modern Lisp Machine necessarily use Lisp? I think that it probably has to be a language like Lisp, Smalltalk, Forth or Tcl. It’s hard to put into words what these very different languages share that languages such as C, Java and Python lack, but I think that maybe it reduces down to elegant dynamism?