- Poor typography support: can't embed fonts in files, can't tweak type enough (can't do faux italics for example)
- Subpar file/project management: can't do things like nested folders which gets overwhelming with large projects/teams
- Clunky version control: browsing long file histories is inefficient, the entire VCS UI is forced into a narrow sidebar
Also just off the top of my mind. There's also lots more if you're coming from a print design world and are thus used to Adobe Illustrator.