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0 pointsmattmanser8mo ago0 comments

There's often side effects, including nausea, diarrhea, headaches, bloating, discomfort, etc.

As far as I can tell from forums, it's not like 5% have the side effects, it's like 80-90%.

But for the first time in decades, I felt full. I didn't want to finish a meal, it was too much.

My body regulated my food intake in what felt like a natural way.

I hadn't even realized my body had somehow lost that fundamental mechanism of appetite control. It made me realize I wasn't weak willed, something is different about my body than other people.

But it comes with a price. The side effects I had were quite bad and so I stopped (though I now read that if I switch to a different brand, I might be ok).

I often didn't want to leave the house due to a dicky tummy. It could come/go in waves. But often can last a whole week.

Plus you've got to inject yourself every week. Often you can't drink as it makes you sick. Even when you're doing everything 'right' you can feel a bit off.

If you do over-indulge (with food or drink) the side effects can sometimes be massively amplified and you feel terrible for days.

So amazing in some ways, but it's not like taking a vitamin tablet. There are costs and making one slip up can result in suddenly feeling awful for a day or two.

Perhaps I was just particularly prone to the side effects, but it seems to happen to a lot of people (I found Mumsnet threads about it useful, they are quite revealing as they seem to be fairly honest and willing to share their experiences)

0 comments

JoshTriplett8mo ago

> As far as I can tell from forums, it's not like 5% have the side effects, it's like 80-90%.

Happy people with no issues are less likely to post, or post as often.

That said, much sympathy for the people who do experience particularly bad side effects.

Sammi8mo ago

Same with reviews. If sellers don't proactively ask for reviews from happy customers, then you're often only going to see negative reviews.

This must be an existing named bias, but my google foo is failing me.

sroussey8mo ago

From the people I know on trizepitide, side effects were strongest when upping the dosage in the protocol, particularly two days after. The advice I have received while considering it:

- change your diet. you can't eat the same food at the same volume. or even is smaller volume if the food is a burger, etc.

- watch your drinking, your tolerance for alcohol is reset, and again on the volume thing

- drink a lot of water. apparently opposite to all the volume warnings above, lol

- split dosage and inject twice a week. (i dunno, talk to your doctor. also this only works when you have a vial and not the auto-injectors, though apparently the autoinjectors are way more expensive)

On the other hand, when i ask about what happens if you go on a bender and eat two burgers and lots of fries and drink a six pack?? From people that used to gladly do that: "gross, why would i do that?" That there is the real change.

b3lvedere8mo ago

So, in a way it tortures you so much, that your brain/psyche has no other choice to very quickly adapt to it and stop you from doing the old habits that used to give comfort and joy?

sroussey8mo ago

Perhaps like giving a teen a whole carton of cigarettes to smoke.

loeg8mo ago

I had more side effects ramping up the dose than after a while at the same dose. But they were all fairly mild. (I'm on 5mg/week of Tirzepatide; higher doses probably have more side effects.)

> If you do over-indulge (with food or drink) the side effects can sometimes be massively amplified and you feel terrible for days.

Never had anything like that.

rsynnott8mo ago

> As far as I can tell from forums, it's not like 5% have the side effects, it's like 80-90%

This is likely a sampling error, and you see it with all drugs to some extent. No-one goes on a forum to announce to the world that they’re not having any side effects from [whatever].

AuryGlenz8mo ago

I’m sorry, but as one of the rare (decently) fit & nondiabetic people that have taken these drugs I’m going to call out your comment a bit.

While I have no doubt that obese people have gradually made appetite control harder for themselves, the full feeling you get on GLP meds is in no way the way us normal-weight people feel.

I too, could easy eat a whole bag of doritos after some pizza and then decide I want ice cream. I don’t do that because I know it’s an awful idea and so I maybe just have a pickle after the pizza instead.

On GLP-1 medications at a decent dose I don’t know if I could force myself to eat anything after half of my normal serving of pizza.

That’s not the way the rest of us normally are apart from rare exceptions, I assure you.

stavros8mo ago

Yeah but right now we're just arguing about how strong each person's feeling of "I could eat more" is.

Personally, I really like how, on the medication, it's easy to say "nah, I'd better not". Off the medication, it's impossible, as I have to eat whatever is in front of me, or I won't stop thinking about it.

AuryGlenz8mo ago

Sure, obviously there's no real way to compare that. I was just pointing out that the way it makes people feel isn't natural - as in, that's not how most skinny people feel either.

mattmanserOP8mo ago

What's with the body shaming mate?

I literally have no feeling of 'full'. I used to. I have no idea when it stopped working, but it definitely stopped working.

You can't know what I feel. I can't know what you feel. I'm fit, I have zero appetite control.

If I stop doing tons of exercise, boom, problems. I got old, I stopped moving as much, boom, problems.

People like you are part of the problem, not the solution.

Honestly, you wouldn't say this shit to someone's face.

It was honestly hard enough posting this here in the first place and then a dick like you comes along.

Cheers thanks for ruining my day you prat.

AuryGlenz8mo ago

I apologize for ruining your day, that wasn't my intention. As I stated in my post I don't doubt that obese people have screwed up that signaling over time. Are your cravings off medication worse than mine? Probably. We'd pretty quickly get in to a "Is your green my green?" type discussion talking about that, which obviously has no conclusion. However, I've seen many, many people repeat something along the lines of "Wow, I guess this is what skinny people feel like all the time!" in reference to these medications. I was just pointing out that it absolutely is not how we feel, and I'm one of the fairly rare people out there that can confirm that.

DrillShopper8mo ago

The one thing that helped blunt the side effects for me was cannabis. Just a few puffs at night on the three nights after my injection made a huge difference.

I wouldn't recommend that to everyone, but it helped a lot for me.

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