Tirzepatide is the most potent GLP1
https://glp1.guide/content/semaglutide-vs-tirzepatide-clinic...
Before I started experiments on "my lab rat" with retatrutide, I found that combination of the about half max dose of semaglutide and 1/3 of Max dose of tirzepatide had the best combination of losing weight and lowering side effects. But another "lab rat" did not respond that well to this combo and we keep adjusting it.
Retatrutide so far looks the most compatible, but it is sample of 1.
That said, Reta is a triple agonist[0] and it seems to be quite amazing with good muscle retention as well -- it's unclear if this is just the people who are taking it being more likely to be gym goers. Up until now the only formulation I've seen that specifically targets preserving muscle is GLP1s in combination with bimagrumab[1].
[0]: https://glp1.guide/content/a-new-glp1-retatrutide/
[1]: https://glp1.guide/content/preserving-muscle-glp1s-with-bima...
A fancy way of saying: I *think* Semaglutide is best.
Unless you mean that Semaglutide worked best for you, right now the research points at Tirzepatide being most effective for weight loss (says nothing about t2d though).
