I worry about the Win95-era "Microsoft Pragmatism" at work and a concrete example which comes to mind is nullability. In the nice modern software I often work on I can say some function takes a string and in that program C# will tell me that's not allowed to be null, it has to be an actual string - a significant engineering benefit. But, the CLR does not enforce such rules, so that function may still receive a null instead e.g. if called by some ten year old VB.NET code which has no idea about "nullability" and so just fills out a null for that parameter anyway.

Of course the CLR memory model might really be set in stone and 100% proof against such problems, but I haven't seen anything to reassure me as I did for Java and I fear that if it were convenient for Windows to not quite do that work they would say eh, good enough.