The way I thought about it was that I would gladly pay $500 to have a reduction in RSI symptoms, let alone prevent them beforehand. Not to mention the potential loss of enjoyment & employment from pain during computer use.

And as such, I'm an extremely satisfied Advantage 360 Pro user. The Adv 360 + a mouse side-grade massively reduced pains in my hands/wrists to the point where I don't notice any issues 99% of the time, even with heavy (7+ hour) computer use and quite a lot of FPS gaming.

Though note that there are several keyboards with split layouts + tenting (the two most important aspects for relief) that cost a fraction of the Adv 360; $200-300 of the price tag is for features, build quality, it being pre-built, and ease of programmability.