>1. Studies use large, population-based sample sizes and their effects are based on their statistical significance on these populations. In other words, "side effects" are a population-level phenomenon, not an individual phenomenon. It is plausible that individual side effects are hidden as statistical noise. This is a problem with pharmacological studies as well and there is no easy solution to it AFAIK.

I don't get it, are you trying to imply there might be 0.0001% of people with negative side effects, they're not getting picked up, and for that reason those substances should have never been approved? If so what does that say about allergens? If the Colombian exchange happened today, should we ban peanuts on the basis that a few percent of people get side effects?

>but it is blindingly obvious (to me, at least) that the meat of the problem is environmental, primarily diets, and these compounds are wreaking havoc on the endocrine systems of the population causing a massive uptick in obesity and diabetes.

How is it "blindingly obvious" that it's caused by artificial colors specifically though? Otherwise it's a leap to go from "there must be something in the food" to "we should ban artificial colors".